Toxicology Consultants & Assessment Specialists, LLC

Mold in Motor Home Causes Aspergilloma

This case study illustrates the role of toxicological weight-of-evidence (WOE) in a case involving exposure to mold inside a motor home. It also illustrates how analytical measurements and medical history can be considered as evidential in a toxicological analysis.

Bumpy Panels and Spongy Floors

Shortly after purchasing a new motor home, the owner noticed wind noise and water leaks along the doors and windows as well as interior panels which had become "bumpy" and discolored. At one point upon opening the glove box, the owner found mildewed vehicle paperwork floating in water. Subsequent repairs were made by the dealer on several occasions. The owner later took the vehicle on a trip to Florida and left it parked for a month unattended.

Defects in a new motor home allowed water intrusion, resulting in mold formation
Defects in a new motor home allowed water intrusion, resulting in mold formation.[a]

Upon returning, mushrooms and mold were found growing in numerous locations. The dealer again supposedly made repairs. Later, upon noting a "musky" smell and removing the interior panels, the owner found one entire wall covered with black mold. Peeled-back carpets revealed a black and spongy floor. The owner attempted to clean and remove the mold without respiratory protection and continued to reside in the vehicle while in Florida.

Several months later, a suspicious spot on the owner's lung was discovered during a regular medical scan. Due to a family history of lung cancer, physicians opted to excise the growth surgically. The pathology report confirmed that the spot was an aspergilloma (fungus ball) growing on the lung. Independent expert sampling of the vehicle's air measured an Aspergillus count of 5,020 cfu (colony forming units) per m3 and a Stachybotrys count of 78 cfu/m.3 These very high spore concentrations were obtained "post-remediation."

Black mold growing under and behind passenger seats
Black mold growing under and behind passenger seats.[b]

Causation Methodology

The owner filed a lawsuit for damages, alleging negligence of both the manufacturer and the repair shop(s). Dr. Sawyer was retained to perform an independent causation assessment as an expert toxicologist for the plaintiff. Defendants contended that the plaintiff's lung growth was not an aspergilloma and/or was spontaneous and not related to the mold in the motor home. Defendants noted plaintiff's demonstrable medical history with respect to respiratory infections and attempted to characterize the malady as "merely the latest in a pattern." They contended that the particular mold species in the vehicle could not have caused the aspergilloma for which plaintiff had been diagnosed. They further objected to the methodology used to determine the type(s) and quantities of mold present — and moved to strike the results.

A pertinent issue with respect to causation in this matter was the fact that air sampling was conducted long after exposure and only as a "snapshot" in time rather than samples acquired over multiple days or weeks during the exposure interval. Additionally, spores can heavily concentrate in small, undisturbed areas and may appear far less numerous in larger-volume locations. Thus, air concentration alone was insufficient to establish specific causation.

The Role of Weight-of-Evidence

Specific causation is more difficult to demonstrate than general causation. The toxicologist must satisfy a stringent set of conditions before a causative conclusion is reached. Dr. Sawyer elected to apply a weight-of-evidence (WOE) approach to his assessment using the toxicological methodology developed by Sir Bradford Hill for inferring causation. In practice, this amounts to exhaustive research and a process of elimination achieved by thoroughly reviewing several types of evidence. This includes the documented effects of the plaintiff's exposure and medical history as well as all of the available experimental and human epidemiological literature.

Dr. Sawyer consulted the U.S. indoor air quality standards. He performed a thorough review of the available toxicological journals and relevant peer-reviewed studies (upon which much of the regulatory guidance is based). He assessed plaintiff's medical history and reviewed chest x-rays over a period of years during which he established that plaintiff's medical treatment had resulted in a condition called neutropenia, a compromising of the immune system. In his final report, Dr. Sawyer stated:

Black mold growing underneath carpeting
Black mold growing underneath carpeting.[c]
  • The generally-accepted, peer-reviewed literature cites immunodeficiency and neutropenia as major risk factors for invasive pulmonary aspergillosis. The risk of pulmonary aspergillosis correlates strongly with the duration and degree of neutropenia.
  • Plaintiff had been prescribed corticosteroids (Prednisone) for treatment of a rotator cuff injury during the period of exposure. Various toxicological studies cite three weeks of steroid therapy as a risk factor for aspergillosis.
  • A study of aspergillosis cases from 24 medical centers1 revealed that one-third of patients diagnosed with aspergillosis had received corticosteroids. The study cited corticosteroid use as a contributing factor to the documented aspergillosis diagnoses.
  • Measured levels of Aspergillus and Stachybotrys in the motor home air (5,020 cfu/m3 and 78 cfu/m3 respectively) were in the extreme upper range of any values reported in the toxicological literature. Concentrations of spores can accumulate within a small, enclosed area particularly in the absence of air movement. The Indoor Air Quality Association2 recommends that no individual fungal organism should contribute more than 50 cfu/m.3
  • The timeline associated with the circumstances was in every respect consistent with plaintiff's exposure history and testimony (e.g. the discovery of mold, the supposed vehicle repairs, the frequency of exposure, the calculated dose and the subsequent discovery of the aspergilloma during a routine medical exam).
  • A thorough review and investigation of other possible causes either ruled them out entirely or rendered them so unlikely as to be safely discounted in this matter.
Mold and mildew growing under upholstery
Mold and mildew growing under upholstery.[d]

Dr. Sawyer's report concluded that the available toxicological evidence was entirely consistent with plaintiff's testimony. He presented a specific causative opinion that plaintiff had been afflicted with aspergilloma through repeated exposure to concentrated toxic mold spores in an enclosed indoor area during the same period of time that plaintiff had been rendered more susceptible to such infection through regular corticosteriod treatments and immunodeficiency.

Daubert Challenge

Defendants took strong exception to Dr. Sawyer's report and filed a federal court motion to exclude it under the Daubert Standard which provides rules of evidence governing the admissibility of expert witness testimony during legal proceedings. Defendants' Motion To Exclude contended that Dr. Sawyer's methodology was flawed and his conclusions unreliable.

Defendants further contended that Dr. Sawyer's testimony should be excluded because he did not perform any independent testing of the motor home. However, many years had elapsed between the first discovery of mold growth and Dr. Sawyer's retention as plaintiff's expert. Since "independent testing" would have been impossible, Dr. Sawyer relied on earlier testing performed by a CIH (Certified Induistrial Hygenist).

Defendants had retained an industrial engineering expert who specialized in molds and fungi. He contended that (a) all of the mold in the motor home "might" have been some other species and further contended that (b) there can be no "potential" causative relationship (despite the measured levels of mold spores in the air samples); therefore, none of plaintiff's expert reports (including Dr. Sawyer's) could be considered to be scientifically reliable — and should, therefore, be excluded.

Dr. Sawyer pointed out in his rebuttal that it was not his opinion that plaintiff had been infected with invasive Aspergillosis, but rather was hosting a species of Aspergillus within her lung. With regard to defendants' contentions, Dr. Sawyer noted that defendants' own expert had published materials to the effect that (a) Aspergillus and Penicillium species are two of the most ubiquitous fungi known, (b) it is common for both species to be present indoors, (c) high concentrations of airborne spores can exist in contaminated indoor areas, (d) Aspergillus spores can pose health risks when inhaled, and (e) they are known to cause respiratory symptoms and diseases. Dr. Sawyer noted that it was not possible to reconcile these facts with expert testimony that "...there can be no potential causative relationship." This self-contradiction strongly suggested a lack of objectivity on the part of defendants' expert.

Black mold growing under wall coverings
Black mold growing under wall coverings.[e]

Dr. Sawyer further noted in his rebuttal that the factors cited by regulatory agencies3 with regard to indoor air quality and building dynamics closely mirrored plaintiff's own exposure. Dr. Sawyer additionally noted that all causative factors relevant to the circumstances had been addressed in his assessment. These included:

  1. Strength of association between the exposure and a particular health effect
  2. Specificity of the association
  3. Consistency of the association
  4. Dose-responsiveness of the chemical
  5. Biological plausibility of the causal connection
  6. Coherence of the association
  7. Temporality (time relationships)
  8. Relevant experimental data


Dr. Sawyer presented the court with an objective opinion of specific causation through application of weight-of-evidence and the Bradford Hill method of causative determination. In its ruling, the court noted that defendants' own expert stated that there is currently no reliable method to determine the level of airborne toxins in an indoor environment — but Dr. Sawyer's opinions were not based solely on air samples. With respect to Dr. Sawyer in particular, the court stated:

Dr. Sawyer's analysis and opinions establish specific causation and are sufficiently supported by scientific data and evidence in the record. Before concluding that plaintiff's exposure to the levels of toxic mold in the vehicle is consistent with the diagnosis of aspergilloma, Dr. Sawyer detailed plaintiff's pertinent medical history, weakened immune system, family's medical history, and history of hospitalizations and cigarette smoking. He also noted that aspergillus grows on organic debris and occurs naturally in some outdoor and hospital environments. It is reasonable to infer that Dr. Sawyer took into account, and ultimately ruled out, these possible factors before concluding that the high levels of aspergillus, penicillium, and stachybotrys found in the vehicle caused the medical condition. … Dr. Sawyer noted that the levels of aspergillus found in the vehicle "are in the extreme upper range of any values ever reported in the literature for living quarter environments." … [therefore] defendants' motion to preclude plaintiff's expert is DENIED.


The court's written ruling characterized defendants' objections as "unpersuasive." The inclusion of Dr. Sawyer's toxicological assessment and testimony significantly undermined defendants' credibility and position in litigation. Defendants elected to settle the case ahead of a likely jury verdict in favor of plaintiff.

(Disclaimer: Toxicology case studies are impartial and objective summaries of toxicological matters in which TCAS was retained for the purpose of assessing health-based factors which, in some cases, led to a determination of causation. No names or identifying information have been provided due to privacy and legal considerations. In the above matter, Dr. Sawyer was retained by plaintiff.)

Notes and References

  1. Perfect, JR, et al., "The impact of culture isolation of Aspergillus species: a hospital-based survey of aspergillosis," 2001, Clinical Infectious Diseases, Vol. 33, pages 1824-1833.
  2. Indoor Air Quality Association, Inc., "Recommended guidelines for indoor environments," IAQA01-2000, Longwood, Florida.
  3. New York City Department of Health and Mental Hygiene, "Guidelines on assessment and remediation of fungi in indoor environments," Appendix A, November 2008


  1. Photo by TCAS © Copyright 2017, adapted from case report
  2. Photo by TCAS © Copyright 2017, adapted from case report
  3. Photo by TCAS © Copyright 2017, adapted from case report
  4. Photo by TCAS © Copyright 2017, adapted from case report
  5. Photo by TCAS © Copyright 2017, adapted from case report

A Message from Dr. William R. Sawyer
Chief Toxicologist, TCAS, LLC

A message from Dr. William R. Sawyer, Expert Toxicologist

"Mold and fungi can produce toxic reactions including invasive growths, irritation of eyes, nose and throat, wheezing and exacerbation of asthma. Only a full toxicological assessment can quantify an exposure, especially if refuting or demonstrating causation."

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